2V4B

Crystal Structure of Human ADAMTS-1 catalytic Domain and Cysteine- Rich Domain (apo-form)

Summary for 2V4B

• Entry DOI: 10.2210/pdb2v4b/pdb
• Related: 2JIH
• Descriptor: ADAMTS-1, ZINC ION, CADMIUM ION, ... (7 entities in total)
• Functional Keywords: zymogen, protease, adamts-1, hydrolase, metalloprotease, heparin-binding, metalloproteinase, metzincin, glycoprotein, metal-binding, extracellular matrix, cleavage on pair of basic residues
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 67390.92

Authors

Gerhardt, S.,Hassall, G.,Hawtin, P.,McCall, E.,Flavell, L.,Minshull, C.,Hargreaves, D.,Ting, A.,Pauptit, R.A.,Parker, A.E.,Abbott, W.M. (deposition date: 2007-06-28, release date: 2008-01-15, Last modification date: 2019-04-24)

• Primary citation: Gerhardt, S.,Hassall, G.,Hawtin, P.,Mccall, E.,Flavell, L.,Minshull, C.,Hargreaves, D.,Ting, A.,Pauptit, R.A.,Parker, A.E.,Abbott, W.M.; Crystal Structures of Human Adamts-1 Reveal a Conserved Catalytic Domain and a Disintegrin-Like Domain with a Fold Homologous to Cysteine-Rich Domains.; J.Mol.Biol., 373:891-, 2007; PubMed: 17897672; DOI: 10.1016/J.JMB.2007.07.047

Experimental method

X-RAY DIFFRACTION (2 Å)