2RD0
Structure of a human p110alpha/p85alpha complex
Summary for 2RD0
Entry DOI | 10.2210/pdb2rd0/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (2 entities in total) |
Functional Keywords | disease mutation, kinase, oncogene, transferase, host-virus interaction, phosphorylation, sh2 domain, sh3 domain, transferase-oncoprotein complex, transferase/oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 161489.54 |
Authors | Huang, C.,Gabelli, S.B.,Amzel, L.M. (deposition date: 2007-09-20, release date: 2007-12-25, Last modification date: 2024-02-21) |
Primary citation | Huang, C.H.,Mandelker, D.,Schmidt-Kittler, O.,Samuels, Y.,Velculescu, V.E.,Kinzler, K.W.,Vogelstein, B.,Gabelli, S.B.,Amzel, L.M. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science, 318:1744-1748, 2007 Cited by PubMed: 18079394DOI: 10.1126/science.1150799 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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