2R3K

Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor

Summary for 2R3K

Entry DOI	10.2210/pdb2r3k/pdb
Related	2R3F 2R3G 2R3H 2R3I 2R3J 2R3L 2R3M 2R3N 2R3O 2R3P 2R3Q 2R3R
Descriptor	Cell division protein kinase 2, 3-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amine (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, cell cycle, inhibition, cyclin-dependent kinase, cancer, atp-binding, cell division, mitosis, nucleotide-binding, phosphorylation, polymorphism, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34414.77
Authors	Fischmann, T.O.,Hruza, A.W.,Madison, V.M.,Duca, J.S. (deposition date: 2007-08-29, release date: 2008-01-22, Last modification date: 2011-07-13)
Primary citation	Fischmann, T.O.,Hruza, A.,Duca, J.S.,Ramanathan, L.,Mayhood, T.,Windsor, W.T.,Le, H.V.,Guzi, T.J.,Dwyer, M.P.,Paruch, K.,Doll, R.J.,Lees, E.,Parry, D.,Seghezzi, W.,Madison, V. Structure-guided discovery of cyclin-dependent kinase inhibitors. Biopolymers, 89:372-379, 2008 Cited by PubMed: 17937404 DOI: 10.1002/bip.20868 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation