2R38

I84V HIV-1 protease mutant in complex with a carbamoyl decorated pyrrolidine-based inhibitor

Summary for 2R38

Entry DOI	10.2210/pdb2r38/pdb
Related	2R3T 2R3W 2R43
Descriptor	Protease, CHLORIDE ION, 4,4'-{(3S,4S)-PYRROLIDINE-3,4-DIYLBIS[(BENZYLIMINO)SULFONYL]}DIBENZAMIDE, ... (4 entities in total)
Functional Keywords	protein-ligand complex, aspartyl protease, hydrolase, protease
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22298.13
Authors	Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-08-29, release date: 2008-09-02, Last modification date: 2023-08-30)
Primary citation	Bottcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. Structural and Kinetic Analysis of Pyrrolidine-Based Inhibitors of the Drug-Resistant Ile84Val Mutant of HIV-1 Protease J.Mol.Biol., 383:347-357, 2008 Cited by PubMed: 18692068 DOI: 10.1016/j.jmb.2008.07.062 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation