2R24

Human Aldose Reductase structure

Summary for 2R24

Entry DOI	10.2210/pdb2r24/pdb
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (4 entities in total)
Functional Keywords	beta/alpha-8 tim barrel, cataract, nadp, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	37057.98
Authors	Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.N.,Cousido-Siah, A.,Haertlein, M.,Joachimiak, A.,Myles, D.,Podjarny, A. (deposition date: 2007-08-24, release date: 2008-12-23, Last modification date: 2024-02-21)
Primary citation	Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.N.,Cousido-Siah, A.,Haertlein, M.,Joachimiak, A.,Myles, D.,Podjarny, A. Quantum model of catalysis based on mobile proton revealed by subatomic X-Ray and neutron diffraction studies of h-Aldose Reductase Proc.Natl.Acad.Sci.USA, 105:1844-1848, 2008 Cited by PubMed: 18250329 DOI: 10.1073/pnas.0711659105 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2.194 Å) X-RAY DIFFRACTION (1.752 Å)

Structure validation