2QXW

Perdeuterated alr2 in complex with idd594

Summary for 2QXW

• Entry DOI: 10.2210/pdb2qxw/pdb
• Related: 1US0
• Descriptor: Aldose reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, IDD594, ... (5 entities in total)
• Functional Keywords: oxidoreductase, nadp, idd594, cataract
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37444.25

Authors

Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.,Cousido-Siah, A.,Joachimiak, A.,Myles, D.,Podjarny, A. (deposition date: 2007-08-13, release date: 2008-01-22, Last modification date: 2023-08-30)

• Primary citation: Blakeley, M.P.,Ruiz, F.,Cachau, R.,Hazemann, I.,Meilleur, F.,Mitschler, A.,Ginell, S.,Afonine, P.,Ventura, O.N.,Cousido-Siah, A.,Haertlein, M.,Joachimiak, A.,Myles, D.,Podjarny, A.; Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase.; Proc.Natl.Acad.Sci.Usa, 105:1844-1848, 2008; PubMed: 18250329; DOI: 10.1073/pnas.0711659105

Experimental method

X-RAY DIFFRACTION (0.8 Å)