2QJU
Crystal Structure of an NSS Homolog with Bound Antidepressant
Summary for 2QJU
Entry DOI | 10.2210/pdb2qju/pdb |
Related | 2A65 |
Descriptor | Transporter, octyl beta-D-glucopyranoside, SODIUM ION, ... (7 entities in total) |
Functional Keywords | neurotransmitter, transmembrane transport, integral membrane protein, antidepressant, nss, transport protein, structural genomics, psi-2, protein structure initiative, new york consortium on membrane protein structure, nycomps |
Biological source | Aquifex aeolicus |
Total number of polymer chains | 1 |
Total formula weight | 58770.69 |
Authors | Zhou, Z.,Karpowich, N.K.,Wang, D.N.,New York Consortium on Membrane Protein Structure (NYCOMPS) (deposition date: 2007-07-09, release date: 2007-08-21, Last modification date: 2023-08-30) |
Primary citation | Zhou, Z.,Zhen, J.,Karpowich, N.K.,Goetz, R.M.,Law, C.J.,Reith, M.E.,Wang, D.N. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science, 317:1390-1393, 2007 Cited by PubMed: 17690258DOI: 10.1126/science.1147614 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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