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2QJA

Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12

Summary for 2QJA
Entry DOI10.2210/pdb2qja/pdb
Related1ES7 1REW 2QJ9 2QJB 3BMP
DescriptorBone morphogenetic protein 2, Bone morphogenetic protein receptor type IA (3 entities in total)
Functional Keywordsligand-receptor complex, chondrogenesis, cleavage on pair of basic residues, cytokine, developmental protein, differentiation, glycoprotein, growth factor, osteogenesis, atp-binding, disease mutation, kinase, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase, transmembrane, cytokine-receptor complex, cytokine/receptor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P12643
Membrane; Single-pass type I membrane protein: P36894
Total number of polymer chains4
Total formula weight55506.88
Authors
Kotzsch, A.,Mueller, T.D. (deposition date: 2007-07-06, release date: 2008-01-15, Last modification date: 2023-08-30)
Primary citationKotzsch, A.,Nickel, J.,Seher, A.,Heinecke, K.,van Geersdaele, L.,Herrmann, T.,Sebald, W.,Mueller, T.D.
Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283:5876-5887, 2008
Cited by
PubMed: 18160401
DOI: 10.1074/jbc.M706029200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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