2QD9
P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds
Summary for 2QD9
Entry DOI | 10.2210/pdb2qd9/pdb |
Descriptor | Mitogen-activated protein kinase 14, 1-[5-[[3-[2,4-bis(fluoranyl)phenyl]-6,8-dihydro-5~{H}-imidazo[1,5-a]pyrazin-7-yl]carbonyl]-6-methoxy-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-2-[(3~{R})-3-oxidanylpyrrolidin-1-yl]ethane-1,2-dione (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase, kinase, transferase, p38 map kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42655.52 |
Authors | Sack, J.S. (deposition date: 2007-06-20, release date: 2007-08-21, Last modification date: 2024-02-21) |
Primary citation | Murali Dhar, T.G.,Wrobleski, S.T.,Lin, S.,Furch, J.A.,Nirschl, D.S.,Fan, Y.,Todderud, G.,Pitt, S.,Doweyko, A.M.,Sack, J.S.,Mathur, A.,McKinnon, M.,Barrish, J.C.,Dodd, J.H.,Schieven, G.L.,Leftheris, K. Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds. Bioorg.Med.Chem.Lett., 17:5019-5024, 2007 Cited by PubMed: 17664068DOI: 10.1016/j.bmcl.2007.07.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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