2QCS
A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state
Summary for 2QCS
Entry DOI | 10.2210/pdb2qcs/pdb |
Related | 1APM 1NE4 1NE6 1RGS |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, MANGANESE (II) ION, ... (9 entities in total) |
Functional Keywords | cyclic adenosine monophosphate, camp-dependent protein kinase, pka holoenzyme, cyclic nucleotide binding domain, protein-protein interaction, conformational change, protein binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (house mouse) More |
Cellular location | Cytoplasm . Isoform 2: Cell projection, cilium, flagellum : P05132 Cell membrane : P00514 |
Total number of polymer chains | 2 |
Total formula weight | 75151.43 |
Authors | Kim, C.,Cheng, C.Y.,Saldanha, A.S.,Taylor, S.S. (deposition date: 2007-06-19, release date: 2007-11-06, Last modification date: 2023-08-30) |
Primary citation | Kim, C.,Cheng, C.Y.,Saldanha, S.A.,Taylor, S.S. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130:1032-1043, 2007 Cited by PubMed: 17889648DOI: 10.1016/j.cell.2007.07.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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