2QBR
Crystal structure of ptp1b-inhibitor complex
Summary for 2QBR
Entry DOI | 10.2210/pdb2qbr/pdb |
Related | 2QBP 2QBQ 2QBS |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein-inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35296.04 |
Authors | |
Primary citation | Wilson, D.P.,Wan, Z.K.,Xu, W.X.,Kirincich, S.J.,Follows, B.C.,Joseph-McCarthy, D.,Foreman, K.,Moretto, A.,Wu, J.,Zhu, M.,Binnun, E.,Zhang, Y.L.,Tam, M.,Erbe, D.V.,Tobin, J.,Xu, X.,Leung, L.,Shilling, A.,Tam, S.Y.,Mansour, T.S.,Lee, J. Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J.Med.Chem., 50:4681-4698, 2007 Cited by PubMed: 17705360DOI: 10.1021/jm0702478 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report