2QAK
HIV-1 PR mutant in complex with nelfinavir
Summary for 2QAK
Entry DOI | 10.2210/pdb2qak/pdb |
Related | 2PYM 2PYN 2Q63 2Q64 |
Descriptor | PROTEASE RETROPEPSIN, 2-[2-HYDROXY-3-(3-HYDROXY-2-METHYL-BENZOYLAMINO)-4-PHENYL SULFANYL-BUTYL]-DECAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID TERT-BUTYLAMIDE (3 entities in total) |
Functional Keywords | hiv protease inhibitors; protease-inhibitor structure; isothermal calorimetry; antiviral resistance development, hydrolase |
Biological source | human immunodeficiency virus 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22093.20 |
Authors | Rezacova, P.,Kozisek, M.,Saskova, K.,Brynda, J.,Konvalinka, J. (deposition date: 2007-06-16, release date: 2008-07-01, Last modification date: 2023-08-30) |
Primary citation | Kozisek, M.,Bray, J.,Rezacova, P.,Saskova, K.,Rulisek, L.,Brynda, J.,Pokorna, J.,Mammano, F.,Konvalinka, J. Evolutionary pathway of HIV resistance analyzed on molecular level: Enzymatic activities, 3-D structures and thermodynamics of HIV proteases resistant to nelfinavir To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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