2PVW
A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with 2-(phosphonomethyl)pentanedioic acid (2-PMPA)
Summary for 2PVW
Entry DOI | 10.2210/pdb2pvw/pdb |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase; 2-(phosphonomethyl)pentanedioic acid; 2-(pmpa), hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 82977.01 |
Authors | Barinka, C.,Lubkowski, J. (deposition date: 2007-05-10, release date: 2007-05-22, Last modification date: 2023-08-30) |
Primary citation | Barinka, C.,Rovenska, M.,Mlcochova, P.,Hlouchova, K.,Plechanovova, A.,Majer, P.,Tsukamoto, T.,Slusher, B.S.,Konvalinka, J.,Lubkowski, J. Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J.Med.Chem., 50:3267-3273, 2007 Cited by PubMed: 17567119DOI: 10.1021/jm070133w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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