2PSQ
Crystal Structure of Unphosphorylated Unactivated Wild Type FGF Receptor 2 (FGFR2) Kinase Domain
Summary for 2PSQ
Entry DOI | 10.2210/pdb2psq/pdb |
Related | 1GJO 1OEC 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B |
Descriptor | Fibroblast growth factor receptor 2, SULFATE ION (3 entities in total) |
Functional Keywords | kinase domain fold consisting of n- and c-lobes, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802 |
Total number of polymer chains | 2 |
Total formula weight | 84660.93 |
Authors | Chen, H.,Mohammadi, M. (deposition date: 2007-05-07, release date: 2007-09-25, Last modification date: 2023-08-30) |
Primary citation | Chen, H.,Ma, J.,Li, W.,Eliseenkova, A.V.,Xu, C.,Neubert, T.A.,Miller, W.T.,Mohammadi, M. A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol.Cell, 27:717-730, 2007 Cited by PubMed: 17803937DOI: 10.1016/j.molcel.2007.06.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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