2PNU

Crystal structure of human androgen receptor ligand-binding domain in complex with EM-5744

Summary for 2PNU

• Entry DOI: 10.2210/pdb2pnu/pdb
• Descriptor: Androgen receptor, SULFATE ION, (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE, ... (6 entities in total)
• Functional Keywords: har, dht, androgen receptor, ligand binding domain, lbd, androgen, hormone-gene regulation complex, hormone/gene regulation
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P10275
• Total number of polymer chains: 1
• Total formula weight: 31888.31

Authors

Cantin, L.,Faucher, F.,Couture, J.F.,Pereira de Jesus-Tran, K.,Legrand, P.,Ciobanu, C.L.,Singh, S.M.,Labrie, F.,Breton, R. (deposition date: 2007-04-25, release date: 2007-09-11, Last modification date: 2023-08-30)

• Primary citation: Cantin, L.,Faucher, F.,Couture, J.F.,de Jesus-Tran, K.P.,Legrand, P.,Ciobanu, L.C.,Frechette, Y.,Labrecque, R.,Singh, S.M.,Labrie, F.,Breton, R.; Structural Characterization of the Human Androgen Receptor Ligand-binding Domain Complexed with EM5744, a Rationally Designed Steroidal Ligand Bearing a Bulky Chain Directed toward Helix 12.; J.Biol.Chem., 282:30910-30919, 2007; PubMed: 17711855; DOI: 10.1074/jbc.M705524200

Experimental method

X-RAY DIFFRACTION (1.65 Å)