2P9V

Structure of AmpC beta-lactamase with cross-linked active site after exposure to small molecule inhibitor

Summary for 2P9V

• Entry DOI: 10.2210/pdb2p9v/pdb
• Descriptor: Beta-lactamase, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: beta-lactamase, cross-link, hydrolase
• Biological source: Escherichia coli; More
• Cellular location: Periplasm: P00811 P00811
• Total number of polymer chains: 2
• Total formula weight: 79313.82

Authors

Babaoglu, K.,Wyrembak, P.N.,Pelto, R.B.,Shoichet, B.K.,Pratt, R.F. (deposition date: 2007-03-26, release date: 2007-08-14, Last modification date: 2011-07-13)

• Primary citation: Wyrembak, P.N.,Babaoglu, K.,Pelto, R.B.,Shoichet, B.K.,Pratt, R.F.; O-Aryloxycarbonyl Hydroxamates: New beta-Lactamase Inhibitors That Cross-Link the Active Site.; J.Am.Chem.Soc., 129:9548-9549, 2007; PubMed: 17628063; DOI: 10.1021/ja072370u

Experimental method

X-RAY DIFFRACTION (1.8 Å)