2P4I
Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
Summary for 2P4I
Entry DOI | 10.2210/pdb2p4i/pdb |
Related | 2oo8 |
Descriptor | Angiopoietin-1 receptor, 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE (3 entities in total) |
Functional Keywords | tie-2 kinase inhibitor triazine, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q02763 |
Total number of polymer chains | 2 |
Total formula weight | 73635.77 |
Authors | Bellon, S.F. (deposition date: 2007-03-12, release date: 2007-03-20, Last modification date: 2024-02-21) |
Primary citation | Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Bready, J.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Coxon, A.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Hoffman, D.,Johnson, R.E.,Kendall, R.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Tempest, P.,Wang, L.,Whittington, D.A.,Zhao, H. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J.Med.Chem., 50:611-626, 2007 Cited by PubMed: 17253678DOI: 10.1021/jm061107l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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