2P33

Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors

Summary for 2P33

• Entry DOI: 10.2210/pdb2p33/pdb
• Descriptor: c-Jun N-terminal kinase 3, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3 entities in total)
• Functional Keywords: jnk3 kinase, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P53779
• Total number of polymer chains: 1
• Total formula weight: 42515.62

Authors

Ceska, T.A.,Platt, A.,Fortunato, M.,Dickson, K.M.,Sharpe, A. (deposition date: 2007-03-08, release date: 2007-06-19, Last modification date: 2023-08-30)

• Primary citation: Alam, M.,Beevers, R.E.,Ceska, T.,Davenport, R.J.,Dickson, K.M.,Fortunato, M.,Gowers, L.,Haughan, A.F.,James, L.A.,Jones, M.W.,Kinsella, N.,Lowe, C.,Meissner, J.W.,Nicolas, A.L.,Perry, B.G.,Phillips, D.J.,Pitt, W.R.,Platt, A.,Ratcliffe, A.J.,Sharpe, A.,Tait, L.J.; Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors; Bioorg.Med.Chem.Lett., 17:3463-3467, 2007; PubMed: 17459703; DOI: 10.1016/j.bmcl.2007.03.078

Experimental method

X-RAY DIFFRACTION (2.4 Å)