2OZ2
Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (K11777)
Summary for 2OZ2
Entry DOI | 10.2210/pdb2oz2/pdb |
Descriptor | Cruzipain, SULFATE ION, NALPHA-[(4-METHYLPIPERAZIN-1-YL)CARBONYL]-N-{(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-L-PHENYLALANINAMIDE, ... (4 entities in total) |
Functional Keywords | cysteine protease, covalent inhibitor, vinyl sulfoneamide derived, hydrolase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 2 |
Total formula weight | 47352.27 |
Authors | Rickert, M.,Brinen, L. (deposition date: 2007-02-23, release date: 2008-02-26, Last modification date: 2019-09-04) |
Primary citation | Kerr, I.D.,Lee, J.H.,Farady, C.J.,Marion, R.,Rickert, M.,Sajid, M.,Pandey, K.C.,Caffrey, C.R.,Legac, J.,Hansell, E.,McKerrow, J.H.,Craik, C.S.,Rosenthal, P.J.,Brinen, L.S. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J.Biol.Chem., 284:25697-25703, 2009 Cited by PubMed: 19620707DOI: 10.1074/jbc.M109.014340 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report