Structure of the Skp1-Fbw7-CyclinEdegC complex

Summary for 2OVQ

Related2OVP 2OVR
DescriptorS-phase kinase-associated protein 1A/F-box/WD repeat protein 7/cyclinE C-terminal degron
Functional KeywordsF-box; WD40 domains; double phosphorylation, TRANSCRIPTION-CELL CYCLE COMPLEX,TRANSCRIPTION/CELL CYCLE
Biological sourceHomo sapiens (human)
Cellular locationIsoform 1: Nucleus, nucleoplasm. Isoform 2: Cytoplasm. Isoform 4: Nucleus, nucleolus. Nucleus (By similarity) Q969H0
Total number of polymer chains3
Total molecular weight69228.02
Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P. (deposition date: 2007-02-14, release date: 2007-04-24, modification date: 2011-11-16)
Primary citation
Hao, B.,Oehlmann, S.,Sowa, M.E.,Harper, J.W.,Pavletich, N.P.
Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
Mol.Cell, 26:131-143, 2007
PubMed: 17434132
DOI: 10.1016/j.molcel.2007.02.022
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264242.9%6.3%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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