2OIP

Crystal Structure of the S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis

Summary for 2OIP

Entry DOI	10.2210/pdb2oip/pdb
Descriptor	Chain A, crystal structure of Dhfr, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
Functional Keywords	bifunctional enzyme, transferase, oxidoreductase
Biological source	Cryptosporidium hominis
Total number of polymer chains	5
Total formula weight	309998.65
Authors	Martucci, W.E.,Vargo, M.A. (deposition date: 2007-01-11, release date: 2007-07-17, Last modification date: 2023-08-30)
Primary citation	Doan, L.T.,Martucci, W.E.,Vargo, M.A.,Atreya, C.E.,Anderson, K.S. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis Biochemistry, 46:8379-8391, 2007 Cited by PubMed: 17580969 DOI: 10.1021/bi700531r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation