2OAX

Crystal structure of the S810L mutant mineralocorticoid receptor associated with SC9420

Summary for 2OAX

Entry DOI	10.2210/pdb2oax/pdb
Descriptor	Mineralocorticoid receptor, SPIRONOLACTONE (3 entities in total)
Functional Keywords	aldosterone; steroid receptor; nuclear receptor; transcription factor; activating mutation, hypertension; antagonist; spironolactone, transcription
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P08235
Total number of polymer chains	6
Total formula weight	180707.90
Authors	Huyet, J.,Pinon, G.M.,Fay, M.R.,Rafestin-Oblin, M.E.,Fagart, J. (deposition date: 2006-12-18, release date: 2007-08-14, Last modification date: 2023-08-30)
Primary citation	Huyet, J.,Pinon, G.M.,Fay, M.R.,Fagart, J.,Rafestin-Oblin, M.E. Structural basis of spirolactone recognition by the mineralocorticoid receptor Mol.Pharmacol., 72:563-571, 2007 Cited by PubMed: 17569793 DOI: 10.1124/mol.107.036459 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation