2NVD
Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)
Summary for 2NVD
Entry DOI | 10.2210/pdb2nvd/pdb |
Related | 2FZD 2NVC |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE, ... (4 entities in total) |
Functional Keywords | aldose reductase, tim-barrel, protein-ligand complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37647.61 |
Authors | Steuber, H.,Heine, A.,Klebe, G. (deposition date: 2006-11-12, release date: 2007-04-24, Last modification date: 2023-10-25) |
Primary citation | Steuber, H.,Zentgraf, M.,La Motta, C.,Sartini, S.,Heine, A.,Klebe, G. Evidence for a novel binding site conformer of aldose reductase in ligand-bound state J.Mol.Biol., 369:186-197, 2007 Cited by PubMed: 17418233DOI: 10.1016/j.jmb.2007.03.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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