2NT0

Acid-beta-glucosidase low pH, glycerol bound

Summary for 2NT0

• Entry DOI: 10.2210/pdb2nt0/pdb
• Related: 2NSX
• Descriptor: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• Functional Keywords: cerezyme, glucocerebrosidase, glucosylceramide, hydrolysis, gaucher disease, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 226785.19

Authors

Lieberman, R.L.,Petsko, G.A.,Ringe, D. (deposition date: 2006-11-06, release date: 2006-12-26, Last modification date: 2023-08-30)

• Primary citation: Lieberman, R.L.,Wustman, B.A.,Huertas, P.,Powe, A.C.,Pine, C.W.,Khanna, R.,Schlossmacher, M.G.,Ringe, D.,Petsko, G.A.; Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.; Nat.Chem.Biol., 3:101-107, 2007; PubMed: 17187079; DOI: 10.1038/nchembio850

Experimental method

X-RAY DIFFRACTION (1.79 Å)