2NNJ
CYP2C8dH complexed with felodipine
Summary for 2NNJ
Entry DOI | 10.2210/pdb2nnj/pdb |
Related | 2NNH 2NNI |
Descriptor | Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | cyp2c8; human p450 2c8; monooxygenases; felodipine; plendil; inhibitor complex; palmitic acid, oxidoreductase, electron transport |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P10632 |
Total number of polymer chains | 1 |
Total formula weight | 55599.51 |
Authors | Schoch, G.A.,Yano, J.K.,Stout, C.D.,Johnson, E.F. (deposition date: 2006-10-24, release date: 2007-10-23, Last modification date: 2023-08-30) |
Primary citation | Schoch, G.A.,Yano, J.K.,Sansen, S.,Dansette, P.M.,Stout, C.D.,Johnson, E.F. Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J.Biol.Chem., 283:17227-17237, 2008 Cited by PubMed: 18413310DOI: 10.1074/jbc.M802180200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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