2NL9
Crystal structure of the Mcl-1:Bim BH3 complex
Summary for 2NL9
Entry DOI | 10.2210/pdb2nl9/pdb |
Related | 1WSX 2NLA |
Descriptor | FUSION PROTEIN CONSISTING OF Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Bcl-2-like protein 11, ZINC ION, ... (5 entities in total) |
Functional Keywords | apoptosis, bcl-2, mcl-1, bim |
Biological source | Mus musculus (Mouse) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521 |
Total number of polymer chains | 2 |
Total formula weight | 21677.93 |
Authors | Czabotar, P.E.,Colman, P.M. (deposition date: 2006-10-19, release date: 2007-03-27, Last modification date: 2023-12-27) |
Primary citation | Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc.Natl.Acad.Sci.USA, 104:6217-6222, 2007 Cited by PubMed: 17389404DOI: 10.1073/pnas.0701297104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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