2KWT

Solution structure of NS2 [27-59]

Summary for 2KWT

• Entry DOI: 10.2210/pdb2kwt/pdb
• Related: 1JY0
• NMR Information: BMRB: 16886
• Descriptor: Protease NS2-3 (1 entity in total)
• Functional Keywords: hepatitis c virus, ns2 domain, membrane protein, viral protein
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): Q9WMX2
• Total number of polymer chains: 1
• Total formula weight: 4054.85

Authors

Montserret, R.,Bartenschlager, R.,Penin, F. (deposition date: 2010-04-19, release date: 2011-03-02, Last modification date: 2011-07-13)

• Primary citation: Jirasko, V.,Montserret, R.,Lee, J.Y.,Gouttenoire, J.,Moradpour, D.,Penin, F.,Bartenschlager, R.; Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly.; Plos Pathog., 6:e1001233-e1001233, 2010; PubMed: 21187906; DOI: 10.1371/journal.ppat.1001233

Experimental method

SOLUTION NMR