2KO7

Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate

Summary for 2KO7

• Entry DOI: 10.2210/pdb2ko7/pdb
• NMR Information: BMRB: 16491
• Descriptor: Peptidyl-prolyl cis-trans isomerase, ethyl (4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}-2,6-dioxopiperidin-1-yl)acetate (2 entities in total)
• Functional Keywords: cis-trans isomerase, fkbp, cycloheximide-n-ethylethanoate, complex, isomerase, rotamase, structural genomics, ssgcid, seattle structural genomics center for infectious disease
• Biological source: Burkholderia pseudomallei (Pseudomonas pseudomallei)
• Total number of polymer chains: 1
• Total formula weight: 12607.14

Authors

Zheng, S.,Leeper, T.,Varani, G.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2009-09-11, release date: 2009-09-29, Last modification date: 2011-11-02)

• Primary citation: Norville, I.H.,O'Shea, K.,Sarkar-Tyson, M.,Zheng, S.,Titball, R.W.,Varani, G.,Harmer, N.J.; The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.; Biochem.J., 437:413-422, 2011; PubMed: 21574961; DOI: 10.1042/BJ20110345

Experimental method

SOLUTION NMR