2K8J

Solution structure of HCV p7 tm2

Summary for 2K8J

• Entry DOI: 10.2210/pdb2k8j/pdb
• NMR Information: BMRB: 15951
• Descriptor: p7tm2 (1 entity in total)
• Functional Keywords: p7 polypeptide, hcv, ion chaneling, transmembrane, viral protein
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662
• Total number of polymer chains: 1
• Total formula weight: 3153.85

Authors

Montserret, R.,Penin, F. (deposition date: 2008-09-12, release date: 2009-01-13, Last modification date: 2011-07-13)

• Primary citation: Montserret, R.,Saint, N.,Vanbelle, C.,Salvay, A.G.,Simorre, J.P.,Ebel, C.,Sapay, N.,Renisio, J.G.,Bockmann, A.,Steinmann, E.,Pietschmann, T.,Dubuisson, J.,Chipot, C.,Penin, F.; NMR structure and ion channel activity of the p7 protein from hepatitis C virus.; J.Biol.Chem., 285:31446-31461, 2010; PubMed: 20667830; DOI: 10.1074/jbc.M110.122895

Experimental method

SOLUTION NMR