2J7T
Crystal structure of human serine threonine kinase-10 bound to SU11274
Summary for 2J7T
Entry DOI | 10.2210/pdb2j7t/pdb |
Descriptor | SERINE/THREONINE-PROTEIN KINASE 10, CALCIUM ION, ACETATE ION, ... (5 entities in total) |
Functional Keywords | kinase, transferase, atp-binding, cell cycle progression, phosphorylation, disease mutation, nucleotide- binding, lymphocyte oriented kinase (lok), serine/threonine- protein kinase, serine/threonine kinase (stk10a) |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35206.28 |
Authors | Pike, A.C.W.,Rellos, P.,Fedorov, O.,Das, S.,Debreczeni, J.,Sobott, F.,Watt, S.,Savitsky, P.,Eswaran, J.,Turnbull, A.P.,Papagrigoriou, E.,Ugochukwa, E.,Gorrec, F.,Umeano, C.C.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2006-10-17, release date: 2006-11-07, Last modification date: 2023-12-13) |
Primary citation | Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S. Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27:704-, 2008 Cited by PubMed: 18239682DOI: 10.1038/EMBOJ.2008.8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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