2J62
Structure of a bacterial O-glcnacase in complex with glcnacstatin
Summary for 2J62
Entry DOI | 10.2210/pdb2j62/pdb |
Descriptor | O-GlcNAcase NagJ, CHLORIDE ION, N-[(5R,6R,7R,8S)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-2-(2-PHENYLETHYL)-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDIN-8-YL]-2-METHYLPROPANAMIDE, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | Clostridium perfringens |
Total number of polymer chains | 2 |
Total formula weight | 134270.11 |
Authors | Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Shepherd, S.M.,Shpiro, N.A.,van Aalten, D.M.F. (deposition date: 2006-09-22, release date: 2007-02-13, Last modification date: 2024-05-08) |
Primary citation | Dorfmueller, H.C.,Borodkin, V.S.,Schimpl, M.,Shepherd, S.M.,Shpiro, N.A.,van Aalten, D.M. GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels. J. Am. Chem. Soc., 128:16484-16485, 2006 Cited by PubMed: 17177381DOI: 10.1021/ja066743n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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