2J4G

Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with n-butyl- thiazoline inhibitor

Summary for 2J4G

Entry DOI	10.2210/pdb2j4g/pdb
Related	2CHN 2CHO 2J47
Descriptor	HYALURONOGLUCOSAMINIDASE, (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ACETATE ION, ... (5 entities in total)
Functional Keywords	gh84, enzyme, thiazoline, inhibition, o-glcnacase, inhibitor
Biological source	BACTEROIDES THETAIOTAOMICRON
Total number of polymer chains	2
Total formula weight	165172.87
Authors	Dennis, R.J.,Davies, G.J. (deposition date: 2006-08-31, release date: 2007-01-30, Last modification date: 2023-12-13)
Primary citation	Whitworth, G.E.,Macauley, M.S.,Stubbs, K.A.,Dennis, R.J.,Taylor, E.J.,Davies, G.J.,Greig, I.R.,Vocadlo, D.J. Analysis of Pugnac and Nag-Thiazoline as Transition State Analogues for Human O-Glcnacase: Mechanistic and Structural Insights Into Inhibitor Selectivity and Transition State Poise. J.Am.Chem.Soc., 129:635-, 2007 Cited by PubMed: 17227027 DOI: 10.1021/JA065697O PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation