2IYA
The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering
Summary for 2IYA
Entry DOI | 10.2210/pdb2iya/pdb |
Descriptor | OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE, ... (4 entities in total) |
Functional Keywords | carbohydrate, glycosylation, glycosyltransferase, enzyme, macrolide, transferase |
Biological source | STREPTOMYCES ANTIBIOTICUS |
Total number of polymer chains | 2 |
Total formula weight | 93609.76 |
Authors | Bolam, D.N.,Roberts, S.M.,Proctor, M.R.,Turkenburg, J.P.,Dodson, E.J.,Martinez-Fleites, C.,Yang, M.,Davis, B.G.,Davies, G.J.,Gilbert, H.J. (deposition date: 2006-07-13, release date: 2007-03-27, Last modification date: 2024-05-08) |
Primary citation | Bolam, D.N.,Roberts, S.M.,Proctor, M.R.,Turkenburg, J.P.,Dodson, E.J.,Martinez-Fleites, C.,Yang, M.,Davis, B.G.,Davies, G.J.,Gilbert, H.J. The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity. Proc.Natl.Acad.Sci.USA, 104:5336-, 2007 Cited by PubMed: 17376874DOI: 10.1073/PNAS.0607897104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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