2IVT
Crystal structure of phosphorylated RET tyrosine kinase domain
Summary for 2IVT
Entry DOI | 10.2210/pdb2ivt/pdb |
Related | 1XPD 2IVS 2IVU 2IVV |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET PRECURSOR, FORMIC ACID, ADENOSINE MONOPHOSPHATE, ... (4 entities in total) |
Functional Keywords | nucleotide-binding, hirschsprung disease, phosphorylation, disease mutation, phosphotransferase, tyrosine-protein kinase, chromosomal translocation, polymorphism, gdnf receptor, transmembrane, proto-oncogene, tyrosine kinase, ret, kinase, membrane, atp-binding, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 36227.49 |
Authors | Knowles, P.P.,Murray-Rust, J.,McDonald, N.Q. (deposition date: 2006-06-16, release date: 2006-08-14, Last modification date: 2023-12-13) |
Primary citation | Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,Scott, R.P.,Hanrahan, S.,Santoro, M.,Ibanez, C.F.,McDonald, N.Q. Structure and chemical inhibition of the RET tyrosine kinase domain. J. Biol. Chem., 281:33577-33587, 2006 Cited by PubMed: 16928683DOI: 10.1074/jbc.M605604200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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