2ITG

CATALYTIC DOMAIN OF HIV-1 INTEGRASE: ORDERED ACTIVE SITE IN THE F185H CONSTRUCT

Summary for 2ITG

Entry DOI	10.2210/pdb2itg/pdb
Descriptor	HUMAN IMMUNODEFICIENCY VIRUS-1 INTEGRASE (2 entities in total)
Functional Keywords	dna integration, aids, polyprotein, hydrolase, endonuclease, polynucleotidyl transferase, dna binding (viral)
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
Total number of polymer chains	1
Total formula weight	17921.45
Authors	Bujacz, G.,Alexandratos, J.,Wlodawer, A.,Zhou-Liu, Q.,Clement-Mella, C. (deposition date: 1996-09-13, release date: 1997-03-12, Last modification date: 2023-08-09)
Primary citation	Bujacz, G.,Alexandratos, J.,Qing, Z.L.,Clement-Mella, C.,Wlodawer, A. The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant. FEBS Lett., 398:175-178, 1996 Cited by PubMed: 8977101 DOI: 10.1016/S0014-5793(96)01236-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation