2IT4
X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet
Summary for 2IT4
Entry DOI | 10.2210/pdb2it4/pdb |
Descriptor | Carbonic anhydrase 1, ZINC ION, PHOSPHONOFORMIC ACID, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase, antiviral, crystal stucture, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00915 |
Total number of polymer chains | 2 |
Total formula weight | 57066.08 |
Authors | Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Supuran, C.T. (deposition date: 2006-10-19, release date: 2007-09-11, Last modification date: 2023-08-30) |
Primary citation | Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Rusconi, S.,Supuran, C.T. Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg.Med.Chem.Lett., 17:2210-2215, 2007 Cited by PubMed: 17314045DOI: 10.1016/j.bmcl.2007.01.113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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