2IL2

Crystal Structure of Human Renin Complexed with Inhibitor

Summary for 2IL2

Entry DOI	10.2210/pdb2il2/pdb
Related	2IKO 2IKU
Descriptor	Renin, N-[2-({2-AMINO-6-ETHYL-5-[4-(3-METHOXYPROPYL)-2,2-DIMETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL]PYRIMIDIN-4-YL}AMINO)ETHYL]NAPHTHALENE-2-SULFONAMIDE, CITRIC ACID, ... (4 entities in total)
Functional Keywords	renin, inhibitors, drug design, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	75963.63
Authors	Mochalkin, I. (deposition date: 2006-10-02, release date: 2006-12-05, Last modification date: 2023-08-30)
Primary citation	Sarver, R.W.,Peevers, J.,Cody, W.L.,Ciske, F.L.,Dyer, J.,Emerson, S.D.,Hagadorn, J.C.,Holsworth, D.D.,Jalaie, M.,Kaufman, M.,Mastronardi, M.,McConnell, P.,Powell, N.A.,Quin, J.,Van Huis, C.A.,Zhang, E.,Mochalkin, I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal.Biochem., 360:30-40, 2007 Cited by PubMed: 17113558 DOI: 10.1016/j.ab.2006.10.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation