2IJN

Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Summary for 2IJN

• Entry DOI: 10.2210/pdb2ijn/pdb
• Related: 2HWH 2HWI 2I1R
• Descriptor: RNA polymerase NS5B, (2R,3R)-3-{[3,5-BIS(TRIFLUOROMETHYL)PHENYL]AMINO}-2-CYANO-3-THIOXOPROPANAMIDE (3 entities in total)
• Functional Keywords: hcv; ns5b; viral rna directed rna polymerase; rdrp; active site; covalent inhibitor, transcription, transferase
• Biological source: Hepatitis C virus subtype 1b
• Total number of polymer chains: 2
• Total formula weight: 128741.20

Authors

Yan, S.,Yao, N. (deposition date: 2006-09-29, release date: 2006-11-28, Last modification date: 2011-07-13)

• Primary citation: Yan, S.,Appleby, T.,Gunic, E.,Shim, J.H.,Tasu, T.,Kim, H.,Rong, F.,Chen, H.,Hamatake, R.,Wu, J.Z.,Hong, Z.,Yao, N.; Isothiazoles as active-site inhibitors of HCV NS5B polymerase; Bioorg.Med.Chem.Lett., 17:28-33, 2007; PubMed: 17049853; DOI: 10.1016/j.bmcl.2006.10.002

Experimental method

X-RAY DIFFRACTION (2.2 Å)