2I80

Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies

Summary for 2I80

Entry DOI	10.2210/pdb2i80/pdb
Descriptor	D-alanine-D-alanine ligase, 3-CHLORO-2,2-DIMETHYL-N-[4-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (3 entities in total)
Functional Keywords	protein-inhibitor complex, ligase
Biological source	Staphylococcus aureus
Cellular location	Cytoplasm (By similarity): Q5HEB7
Total number of polymer chains	2
Total formula weight	82151.38
Authors	Liu, S.,Chang, J.S.,Herberg, J.T.,Horng, M.-M.,Tomich, P.K.,Lin, A.H.,Marotti, K.R. (deposition date: 2006-08-31, release date: 2006-09-26, Last modification date: 2023-08-30)
Primary citation	Liu, S.,Chang, J.S.,Herberg, J.T.,Horng, M.M.,Tomich, P.K.,Lin, A.H.,Marotti, K.R. Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies. Proc.Natl.Acad.Sci.Usa, 103:15178-15183, 2006 Cited by PubMed: 17015835 DOI: 10.1073/pnas.0604905103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation