2I4Z
Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.
Summary for 2I4Z
Entry DOI | 10.2210/pdb2i4z/pdb |
Related | 1PRG 2I4J 2PRG 4PRG |
Descriptor | Peroxisome proliferator-activated receptor gamma, (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID (3 entities in total) |
Functional Keywords | bundle of alpha-helices and a small four-stranded beta-sheet, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 65513.89 |
Authors | Pochetti, G.,Mazza, F. (deposition date: 2006-08-23, release date: 2007-04-17, Last modification date: 2023-08-30) |
Primary citation | Pochetti, G.,Godio, C.,Mitro, N.,Caruso, D.,Galmozzi, A.,Scurati, S.,Loiodice, F.,Fracchiolla, G.,Tortorella, P.,Laghezza, A.,Lavecchia, A.,Novellino, E.,Mazza, F.,Crestani, M. Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands J.Biol.Chem., 282:17314-17324, 2007 Cited by PubMed: 17403688DOI: 10.1074/jbc.M702316200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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