2I4Q
Human renin/PF02342674 complex
Summary for 2I4Q
Entry DOI | 10.2210/pdb2i4q/pdb |
Related | 2G1S 2G21 2G24 |
Descriptor | Renin, (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2-METHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE (3 entities in total) |
Functional Keywords | renin inhibitor, protein-ligand complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 74732.09 |
Authors | Holsworth, D.D.,Jalaie, M.,Zhang, E.,Mcconnell, P.,Mochalkin, I.,Finzel, B.C. (deposition date: 2006-08-22, release date: 2006-10-24, Last modification date: 2011-07-13) |
Primary citation | Powell, N.A.,Ciske, F.L.,Cai, C.,Holsworth, D.D.,Mennen, K.,Van Huis, C.A.,Jalaie, M.,Day, J.,Mastronardi, M.,McConnell, P.,Mochalkin, I.,Zhang, E.,Ryan, M.J.,Bryant, J.,Collard, W.,Ferreira, S.,Gu, C.,Collins, R.,Edmunds, J.J. Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorg.Med.Chem., 15:5912-5949, 2007 Cited by PubMed: 17574423DOI: 10.1016/j.bmc.2007.05.069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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