2I3C

Crystal Structure of an Aspartoacylase from Homo Sapiens

Summary for 2I3C

• Entry DOI: 10.2210/pdb2i3c/pdb
• Related: 2gu2
• Descriptor: Aspartoacylase, ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: canavan disease, n-acetyl-l-aspartate, zinc-dependent hydrolase, aspartoacylase family, aminoacylase-2, acy2, aspa, protein structure initiative, psi, center for eukaryotic structural genomics, cesg, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P45381
• Total number of polymer chains: 2
• Total formula weight: 73269.72

Authors

Bitto, E.,Wesenberg, G.E.,Phillips Jr., G.N.,Mccoy, J.G.,Bingman, C.A.,Center for Eukaryotic Structural Genomics (CESG) (deposition date: 2006-08-17, release date: 2006-08-29, Last modification date: 2023-11-15)

• Primary citation: Bitto, E.,Bingman, C.A.,Wesenberg, G.E.,McCoy, J.G.,Phillips, G.N.; Structure of aspartoacylase, the brain enzyme impaired in Canavan disease.; Proc.Natl.Acad.Sci.Usa, 104:456-461, 2007; PubMed: 17194761; DOI: 10.1073/pnas.0607817104

Experimental method

X-RAY DIFFRACTION (2.8 Å)