2I0H
The structure of p38alpha in complex with an arylpyridazinone
Summary for 2I0H
Entry DOI | 10.2210/pdb2i0h/pdb |
Descriptor | Mitogen-activated protein kinase 14, 2-(3-{(2-CHLORO-4-FLUOROPHENYL)[1-(2-CHLOROPHENYL)-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL]AMINO}PROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | serine/threonine kinase, inhibitor design, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 43241.80 |
Authors | Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Thompson, J.E.,Fitzgerald, C.E.,O'Keefe, S.J. (deposition date: 2006-08-10, release date: 2006-10-17, Last modification date: 2023-08-30) |
Primary citation | Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Fitzgerald, C.E.,Thompson, J.E.,O'Keefe, S.J. p38 MAP Kinase Inhibitors Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design. Bioorg.Med.Chem.Lett., 16:5809-5813, 2006 Cited by PubMed: 16945533DOI: 10.1016/j.bmcl.2006.08.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report