2HKA

Crystal structure of bovine NPC2 and cholesterol sulfate complex

Summary for 2HKA

Entry DOI	10.2210/pdb2hka/pdb
Descriptor	Epididymal secretory protein E1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... (7 entities in total)
Functional Keywords	beta barrel, lipid binding protein
Biological source	Bos taurus (cattle)
Cellular location	Secreted: P79345
Total number of polymer chains	3
Total formula weight	46321.93
Authors	Xu, S.,Gu, L.,Benoff, B.,Stock, A.M. (deposition date: 2006-07-03, release date: 2007-06-26, Last modification date: 2023-08-30)
Primary citation	Xu, S.,Benoff, B.,Liou, H.-L.,Lobel, P.,Stock, A.M. Structural Basis of Sterol Binding by NPC2, a Lysosomal Protein Deficient in Niemann-Pick Type C2 Disease J.Biol.Chem., 282:23525-23531, 2007 Cited by PubMed: 17573352 DOI: 10.1074/jbc.M703848200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation