2HG5

Cs+ complex of a K channel with an amide to ester substitution in the selectivity filter

Summary for 2HG5

• Entry DOI: 10.2210/pdb2hg5/pdb
• Related: 2H8P 2HFE
• Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN, KCSA CHANNEL, ... (6 entities in total)
• Functional Keywords: channel, semi-synthetic, ester, membrane protein
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cell membrane; Multi-pass membrane protein: 2HG5
• Total number of polymer chains: 3
• Total formula weight: 58463.56

Authors

Valiyaveetil, F.I.,MacKinnon, R.,Muir, T.W. (deposition date: 2006-06-26, release date: 2006-09-12, Last modification date: 2024-03-27)

• Primary citation: Valiyaveetil, F.I.,Sekedat, M.,Mackinnon, R.,Muir, T.W.; Structural and Functional Consequences of an Amide-to-Ester Substitution in the Selectivity Filter of a Potassium Channel.; J.Am.Chem.Soc., 128:11591-11599, 2006; PubMed: 16939283; DOI: 10.1021/ja0631955

Experimental method

X-RAY DIFFRACTION (2.75 Å)