2H4K
Crystal structure of PTP1B with a monocyclic thiophene inhibitor
Summary for 2H4K
Entry DOI | 10.2210/pdb2h4k/pdb |
Related | 2AZR 2B07 2H4G |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | protein-drug complex structure, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35190.90 |
Authors | Xu, W.,Wan, Z.-K. (deposition date: 2006-05-24, release date: 2006-08-29, Last modification date: 2024-02-14) |
Primary citation | Wan, Z.K.,Lee, J.,Xu, W.,Erbe, D.V.,Joseph-McCarthy, D.,Follows, B.C.,Zhang, Y.L. Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48. Bioorg.Med.Chem.Lett., 16:4941-4945, 2006 Cited by PubMed: 16806920DOI: 10.1016/j.bmcl.2006.06.051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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