2GH5

Crystal Structure of human Glutathione Reductase complexed with a Fluoro-Analogue of the Menadione Derivative M5

Summary for 2GH5

Entry DOI	10.2210/pdb2gh5/pdb
Descriptor	glutathione reductase, mitochondrial, PHOSPHATE ION, 6-(3-METHYL-1,4-DIOXO-1,4-DIHYDRONAPHTHALEN-2-YL)HEXANOIC ACID, ... (6 entities in total)
Functional Keywords	human glutathione reductase; a fluoro-analogue of the menadione derivative m5, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
Total number of polymer chains	2
Total formula weight	106901.24
Authors	Fritz-Wolf, K.,Winzer, A.,Bauer, H.,Schirmer, H.,Davioud-Charvet, E. (deposition date: 2006-03-25, release date: 2006-09-26, Last modification date: 2023-08-30)
Primary citation	Bauer, H.,Fritz-Wolf, K.,Winzer, A.,Little, S.,Yardley, V.,Vezin, H.,Palfey, B.,Schirmer, R.H.,Davioud-Charvet, E. A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme J.Am.Chem.Soc., 128:10784-10794, 2006 Cited by PubMed: 16910673 DOI: 10.1021/ja061155v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation