2GD8
Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate
Summary for 2GD8
Entry DOI | 10.2210/pdb2gd8/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complexes, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30501.56 |
Authors | De Simone, G.,Di Fiore, A. (deposition date: 2006-03-15, release date: 2007-02-06, Last modification date: 2023-08-30) |
Primary citation | Leese, M.P.,Leblond, B.,Smith, A.,Newman, S.P.,Di Fiore, A.,De Simone, G.,Supuran, C.T.,Purohit, A.,Reed, M.J.,Potter, B.V. 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J.Med.Chem., 49:7683-7696, 2006 Cited by PubMed: 17181151DOI: 10.1021/jm060705x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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