2G50
The location of the allosteric amino acid binding site of muscle pyruvate kinase.
Summary for 2G50
| Entry DOI | 10.2210/pdb2g50/pdb |
| Descriptor | Pyruvate kinase isozymes M1/M2, MANGANESE (II) ION, POTASSIUM ION, ... (10 entities in total) |
| Functional Keywords | allostery, pyruvate kinase, glycolysis, kinase, phosphoryl transfer, transferase |
| Biological source | Oryctolagus cuniculus (rabbit) |
| Cellular location | Cytoplasm : P11974 |
| Total number of polymer chains | 8 |
| Total formula weight | 470798.58 |
| Authors | Holyoak, T.,Williams, R.,Fenton, A.W. (deposition date: 2006-02-22, release date: 2006-05-09, Last modification date: 2024-04-03) |
| Primary citation | Williams, R.,Holyoak, T.,McDonald, G.,Gui, C.,Fenton, A.W. Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase. Biochemistry, 45:5421-5429, 2006 Cited by PubMed: 16634623DOI: 10.1021/bi0524262 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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