2FMN

Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase complex with LY309887

Summary for 2FMN

• Entry DOI: 10.2210/pdb2fmn/pdb
• Related: 2fmo
• Descriptor: 5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, N-[(5-{2-[(6R)-2-AMINO-4-OXO-3,4,5,6,7,8-HEXAHYDROPYRIDO[2,3-D]PYRIMIDIN-6-YL]ETHYL}-2-THIENYL)CARBONYL]-L-GLUTAMIC ACID, ... (4 entities in total)
• Functional Keywords: oxidoreductase, tim barrel, flavin, reductase
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 106436.80

Authors

Pejchal, R.,Campbell, E.,Guenther, B.D.,Lennon, B.W.,Matthews, R.G.,Ludwig, M.L. (deposition date: 2006-01-09, release date: 2006-04-25, Last modification date: 2023-08-30)

• Primary citation: Pejchal, R.,Campbell, E.,Guenther, B.D.,Lennon, B.W.,Matthews, R.G.,Ludwig, M.L.; Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation; Biochemistry, 45:4808-4818, 2006; PubMed: 16605249; DOI: 10.1021/bi052294c

Experimental method

X-RAY DIFFRACTION (2.05 Å)